Symbol
Name
ID

Grb2
growth factor receptor bound protein 2
MGI:95805

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Mouse Phenotypes

increased B cell apoptosis

increased B cell proliferation

decreased thymocyte number

abnormal B cell differentiation

decreased transitional stage T1 B cell number

decreased transitional stage T2 B cell number

abnormal T cell differentiation

decreased double-positive T cell number

decreased mature B cell number

decreased follicular B cell number

increased plasma cell number

decreased B cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased spleen germinal center number

decreased spleen germinal center size

abnormal B cell physiology

decreased IgG3 level

decreased IgG level

increased IgM level

abnormal memory B cell physiology

Availability

Mouse Genotype

Grb2^tm1.1Hua/Grb2^tm1.1Hua
Tg(Lck-cre)1Jtak/0 (conditional)

Grb2^tm1Lnit/Grb2^tm1Lnit
Cd79a^tm1(cre)Reth/Cd79a⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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